https://idereach.com/Journal/index.php/appt/issue/feed 2026-01-23T00:00:00+07:00 Theodorus Rexa Handoyo apptjournal@gmail.com Open Journal Systems <p><strong>Applied Pharmacology and Pharmaceutical Technology (APPT)</strong> is the official scientific publication dedicated to the advancement of pharmacological sciences and pharmaceutical technology. The journal is available in both print and electronic formats and is published two times a year.</p> <p><strong>Applied Pharmacology and Pharmaceutical Technology (APPT)</strong> is a peer-reviewed, open access, international journal which publishes original research papers, reviews, and short communications. The journal welcomes submissions from scholars, researchers, and professionals worldwide.</p> <p>The scope of the journal covers, but is not limited to:</p> <ul> <li> <p>Applied pharmacology, experimental pharmacology, and clinical pharmacology</p> </li> <li> <p>Pharmaceutical technology and formulation science</p> </li> <li> <p>Drug delivery systems and novel dosage forms</p> </li> <li> <p>Pharmaceutical analysis and quality control</p> </li> <li> <p>Biopharmaceutics and pharmacokinetics</p> </li> <li> <p>Biotechnology and bioengineering in pharmaceutical development</p> </li> <li> <p>Pharmacognosy and natural product-based drug development</p> </li> <li> <p>Computational approaches in drug design and development</p> </li> <li> <p>Regulatory sciences and pharmaceutical policy studies</p> </li> </ul> <p>Research at the interface of chemistry, biology, and technology, including innovative methodologies and translational studies, is also encouraged.</p> https://idereach.com/Journal/index.php/appt/article/view/131 2026-01-18T12:57:19+07:00 Theodorus Rexa Handoyo rexahandoyo@gmail.com

<p>Diabetic wound healing is hindered by the interplay of oxidative stress, chronic inflammation, and excessive extracellular matrix degradation, which collectively delay tissue repair. Conventional treatments often address only single pathological pathways, resulting in suboptimal outcomes. This study aimed to evaluate the multitarget potential of rutin, a natural flavonoid, against key proteins implicated in diabetic wound pathology, such as aldose reductase (AKR1B1), cyclooxygenase-2 (COX-2), and matrix metalloproteinase-9 (MMP-9) using molecular docking analysis. The three-dimensional structures of rutin and the target proteins were obtained from the PubChem and Protein Data Bank databases, respectively, and docking simulations were performed using Molegro Virtual Docker 6.0. Rutin exhibited favorable binding affinities toward all targets, with the strongest predicted interaction observed for COX-2 (MolDock score −184.339), followed by AKR1B1 (−169.803) and MMP-9 (−160.330). Hydrogen bond analysis indicated significant contributions to complex stability, particularly for COX-2 and MMP-9. These findings suggest that rutin may modulate oxidative stress, inflammation, and extracellular matrix remodeling simultaneously. Overall, rutin demonstrates promising multitarget potential for diabetic wound healing, warranting further validation through molecular dynamics and experimental studies.</p>

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